So there's a family with a single father, Herb, and three kids, Chuck, Henrietta (she goes by "Henri"), and Tyler. There's no explanation for where the mother is or what happened to her, it's just a single father with three kids living in a house. Herb is a scientist and has an accident at the lab, and the result is that he's just a brain in a jar. His jar is hooked up to this fancy computer, though, and the whole thing is hidden in the basement of the house, which he never leaves. His computer lets him control different robot bodies, one at a time. He's got several different robot bodies -- one of himself, designed to look like Herb's normal body -- one for the kids' nanny, Trudy, that's the girl robot -- another robot, Tad, that's a muscular meathead guy, the kids' "uncle" -- and the fourth and last body, Spencer, a 12-year-old boy, which his kids call their "cousin".
The only people who know that Herb had his accident and is now a brain-in-a-jar are his three kids, and Herb's science partner Ms. Tracy, who helped Herb build the computer and robots and saved his brain after the accident. To the outside world, Herb is still totally fine, he maintains this illusion through using his robot body. The outside world also thinks all the other robot bodies, Trudy, Tad, and Spencer, are normal people, and never catch on that no two of them are ever seen at the same time (because Herb's computer can only control one body at a time). This is the source of many wacky hi-jinks as Herb and his family have to go to great lengths to conceal Herb's true condition from the world.
Herb's kids are Chuck, the oldest at 16 years old, he's a nerd at school and loves science as much as his dad. He helps out with the computer and maintaining the robot bodies, but isn't popular at school because he's so nerdy.
Henri, at 14, is a total jock, and is on every sports team she can sign up for. She tolerates Chuck and his nerdiness, but she's taken a keen liking to her father's Tad body, since Tad is strong and loves to play sports with her.
Tyler, the youngest, is only 8 years old, and doesn't know what he likes yet. He doesn't quite understand all of what's going on with the robots, but loves playing with his dad when his dad uses the Spencer body, and treats the Trudy body as Mom.
Ms. Tracy, at the lab, is Herb's mentor and a few years older than him. She's brilliant, but distant emotionally and cares more about science than people.
None of the other characters are in on the secret. These include Samantha, Henri's coach, who's got a crush on the Tad body.
Michael, the next door neighbor, is prying and obnoxious, and suspects something odd is going on, but doesn't have any idea what.
Paula and Robert, Herb's parents, also aren't in on the secret, although Herb wants to tell them, he's afraid they will react poorly. They don't suspect anything odd at all, because they're too distracted with their own retired activities (such as vacations and cruises) to care.
Manpreet, the sole minority on the cast, is Chuck's best friend and just as nerdy as Chuck. He helps Chuck with the computer stuff, but Chuck must be careful to avoid slipping up and give away too many details.
The episodes' stories basically write themselves. The standard plot revolve around Herb trying to live a normal life through his robot bodies, but getting too excited and taking too much advantage of his robot capabilities, then struggling to allay the suspicion of anyone not in on his secret. He does things that demonstrate far too much strength or knowledge and he gets himself into trouble.
As audiences react well or poorly to different characters, new characters can be added in the form of creating new robot bodies for Herb to use. An entire string of stories can revolve around Herb building some body that he believes to be the most amazing one yet, but, like Icarus, he flies too high and his plans fall apart dramatically.
Episode stories can take turns revolving around each child and their unique challenges in living with their dad as a robot. Other episodes can deal with encounters with friends and family coming to visit unexpectedly, or keeping up appearances while hosting holiday gatherings. "Very special" episode plot lines can consist of standard "coming of age" issues with the children, but skewed by growing up in this unusual situation. Moral messages typically involve Herb learning to put his children's needs above his own.
The show is called No Body's Perfect.